Instrument Breaks the Boundaries of EV Detection, Providing Access to New Data Points
INDIANAPOLIS, USA − (March 19,2024) − Beckman Coulter Life Sciences, a global leader in laboratory
automation and innovation and a subsidiary of Danaher Corporation (NYSE: DHR), continues to lead the
way with first-to-market concepts with the launch of the CytoFLEX nano Flow Cytometer – the first
purpose-built nanoscale flow cytometer for research use only that enables detection to at least 40 nm,*
enabling 30-50% more data creation compared to current marketplace offerings.
With unrivaled sensitivity to detect, count, and characterize nanoparticles using a single analytical
instrument, the CytoFLEX nano Flow Cytometer offers simultaneous multiparameter detection powered
by six fluorescent detection channels and five side scatter channels. It provides global laboratories with a
first-of-its kind solution that lowers the limit of detection and increases resolution to characterize lower
abundance targets in heterogeneous extracellular vesicle (EV) populations between 1 μm and 40 nm
(polystyrene when triggering on violet side scatter).
“The CytoFLEX nano Flow Cytometer shatters the previous limits of detection capabilities, arming
researchers with data they previously would have never been able to access,” said Product Manager
Matthew Goff. “This can open new doors for researchers and enable breakthrough discoveries in our
battle against a myriad of diseases. Extracellular vesicles can be found everywhere, and now researchers
finally have a tool to see what has always been right in front of them. We listened to the needs of our
customers to create an analytical crossroads by increasing sensitivity through enhanced fluidics, optics,
and electronics.”
Nanoparticles are introduced in a hydrodynamic focused stream to the optical system composed of lasers
and detectors. Emitted signals are collected, digitized, and displayed by the electronics and instrument
control software, CytExpert. Multiple automatic on-board cleaning options are offered to control sample-
to-sample carryover and maintain a clean sample line.
“We need to go smaller to expand the realms of research, and there are very few instruments built for
small particle detection alone,” said Alfonso Blanco, Director of the Flow Cytometry Core Technologies in
the University College Dublin. “The CytoFLEX nano Flow Cytometer offers a gold mine of research
discoveries, including the ability to develop complex biomarkers from blood or urine rather than more
invasive tissue means, which means less pain for patients, along with richer results.”
The ergonomic design reduces noise, identifies backgrounds, and reduces carryover issues. Consistent
instrument performance from extensive automated QC processes ensures consistent and reproducible
results every time.
The platform also includes the CytoFLEX, CytoFLEX S, and the CytoFLEX LX flow cytometers, along with
the CytoFLEX SRT cell sorter for research, and the DxFLEX flow cytometer for diagnostic use. Learn
more about the CytoFLEX nano instrument by clicking here.
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About Beckman Coulter Life Sciences With a relentless mission to empower those seeking answers to life’s important scientific questions, Beckman Coulter Life Sciences is a preferred laboratory partner providing automation and innovation solutions for Centrifugation, Flow Cytometry, Genomics, Particle Analysis, and Liquid Handling workflows. With a legacy dating back to 1935, our technologies reduce manual laboratory processes and can provide greater speed, accuracy, and advanced analytics to accelerate answers with a guiding focus to improve patient care and enable pioneering discoveries. Beckman Coulter Life Sciences, part of the Danaher Corporation (NYSE: DHR) family of global science and technology companies, is headquartered in Indianapolis, Indiana with 11 operational hubs around the world and employs approximately 2,800 associates with more than 400,000 systems installed globally. Get to know us by clicking here and by following us on LinkedIn.
* Polystyrene when triggering on violet side scatter. For Research Use Only (RUO), not for use in
diagnostic procedures.
Beckman Coulter, the stylized logo, and the Beckman Coulter product and service marks mentioned herein are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries.
Contact: Matt McCutcheon, Global External Communications Manager
317-719-0557
